Latest at NDPC Laboratory Diagnosis of Dengue Infection
Laboratory Diagnosis of Dengue Infection Print E-mail

Dengue virus is a major cause of acute febrile illness in India specially during and after rainy season. Infection can manifest as dengue fever (DF), dengue haemorrhagic fever (DHF) or dengue shock syndrome (DSS).

The virus is transmitted by female mosquito Aedes aegypti-a day biting mosquito that breeds in pool of stagnant water. Dengue is a global scourge, an indiscriminate disease that continues to grow year upon year. Early diagnosis of the disease is vital. There are four distinct sero-types of the dengue virus - DEN-1, 2, 3 and 4.

Serological Diagnosis of Dengue

Serological diagnosis is a well-recognized and established method for diagnosing acute, active dengue infections. Depending upon the duration of illness Dengue Antibodies, Dengue Antigen(NS1) or both should be performed.

Detection of NS1 antigen though detects disease early but does not provide a differentiation between primary and secondary dengue infection. Differentiation can only be achieved with the use of IgM and IgG antibody detection tools.

Diagnostic Markers of Dengue Infection

The combination of these three markers - IgM, IgG and NS1 provides most comprehensive method for detection of active dengue infection.